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Perspectives in the application of residual dipolar couplings in the structure elucidation of weakly aligned small molecules
Author(s) -
Schmidts Volker
Publication year - 2017
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4543
Subject(s) - chemistry , residual , residual dipolar coupling , dipole , perspective (graphical) , generalization , order (exchange) , molecule , small molecule , algorithm , computer science , epistemology , organic chemistry , artificial intelligence , philosophy , finance , economics , biochemistry
This perspective article aims to review the general methodology in the application of residual dipolar couplings (RDCs) in the structure elucidation of small molecules and give the author's view on challenges for future applications. Recent improvements in the availability of alignment media, new pulse sequences for the measurement of couplings and improvements in the analysis software have garnered widespread interest in the technique. However, further generalization is needed in order to make RDC analysis into a truly “routine” method. Copyright © 2016 John Wiley & Sons, Ltd.