1 H and  13 C NMR spectral assignment of  N , N ′‐disubstituted thiourea and urea derivatives active against nitric oxide synthase | Zendy

Chayah Mariem | Zendy; Camacho M. Encarnación | Zendy; Carrión M. Dora | Zendy; Gallo Miguel A. | Zendy

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1 H and 13 C NMR spectral assignment of N , N ′‐disubstituted thiourea and urea derivatives active against nitric oxide synthase

Author(s) -

Chayah Mariem,

Camacho M. Encarnación,

Carrión M. Dora,

Gallo Miguel A.

Publication year - 2016

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.4455

Subject(s) - chemistry , thiourea , dept , alkyl , urea , aryl , heteronuclear single quantum coherence spectroscopy , carbon 13 nmr , proton nmr , two dimensional nuclear magnetic resonance spectroscopy , medicinal chemistry , nitro , stereochemistry , organic chemistry

The 1 H and 13 C NMR resonances of seventeen N ‐alkyl and aryl‐ N ′‐[3‐hydroxy‐3‐(2‐nitro‐5‐substitutedphenyl)propyl]‐thioureas and ureas ( 1–17 ), and seventeen N ‐alkyl or aryl‐ N ′‐[3‐(2‐amino‐5‐substitutedphenyl)‐3‐hydroxypropyl]‐thioureas and ureas ( 18–34 ), designed as NOS inhibitors, were assigned completely using the concerted application of one‐ and two‐dimensional experiments (DEPT, HSQC and HMBC). NOESY studies confirm the preferred conformation of these compounds. Copyright © 2016 John Wiley & Sons, Ltd.

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