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Use of glass capillaries to suppress thermal convection in NMR tubes in diffusion measurements
Author(s) -
Iwashita Takashi,
Konuma Tsuyoshi,
Harada Erisa,
Mori Shoko,
Sugase Kenji
Publication year - 2016
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4437
Subject(s) - chemistry , convection , diffusion , thermal , analytical chemistry (journal) , spectral line , nuclear magnetic resonance spectroscopy , heteronuclear molecule , molecular diffusion , spectroscopy , nuclear magnetic resonance , chromatography , thermodynamics , metric (unit) , physics , operations management , organic chemistry , quantum mechanics , astronomy , economics
Abstract Diffusion ordered spectroscopy (DOSY) is used to determine the translational diffusion coefficients of molecules in solution. However, DOSY is highly susceptible to spurious spectral peaks resulting from thermal convection occurring in the NMR tube. Thermal convection therefore must be suppressed for accurate estimation of translational diffusion coefficients. In this study, we developed a new method to effectively suppress thermal convection using glass capillaries. A total of 6 to 18 capillaries (0.8‐mm outer diameter) were inserted into a regular 5‐mm NMR tube. The capillaries had minimal effect on magnetic field homogeneity and enabled us to obtain clean DOSY spectra of a mixture of small organic compounds. Moreover, the capillaries did not affect chemical shifts or signal intensities in two‐dimensional heteronuclear single quantum coherence spectra. Capillaries are a simple and inexpensive means of suppressing thermal convection and thus can be used in a wide variety of DOSY experiments. Copyright © 2016 John Wiley & Sons, Ltd.

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