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Distinguishing rotamers in N ‐trifluoroacetyl‐3‐benzazepine derivatives
Author(s) -
AcevedoFuentes Williams A.,
Cassels Bruce K.
Publication year - 2016
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4406
Subject(s) - benzazepine , chemistry , conformational isomerism , ring (chemistry) , carbon 13 nmr , stereochemistry , molecule , organic chemistry
This paper provides the full 13 C NMR assignments for the trifluoroacetamides of five potentially appetite‐reducing 5‐HT 2C benzazepine receptor agonists and two open‐ring synthetic precursors. These compounds exist in solution as mixtures of two rotamers for each of which the 13 C NMR signals have now been assigned with the assistance of 2D NMR experiments and the carbonyl‐induced shifts of the neighboring 13 CH 2 resonances and long‐range 13 C/ 19 F couplings.