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Refinement of the inversion‐transfer NMR experiment for faster characterization of chemical exchange
Author(s) -
Baguet Evelyne
Publication year - 2016
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4320
Subject(s) - chemistry , inversion (geology) , dimethylacetamide , reaction rate constant , transfer function , analytical chemistry (journal) , thermodynamics , kinetics , chromatography , organic chemistry , physics , paleontology , structural basin , solvent , electrical engineering , biology , engineering , quantum mechanics
It is shown theoretically that the inversion‐transfer experiment used to estimate the value of unidirectional rate constants in chemical exchange systems can be performed faster via a reduction of the recovery delay. The chemical exchange rate constants can then be estimated accurately with a formula close to that of standard inversion transfer and easy to use, after a justified approximation. A function was developed to determine the optimal value of the recovery delay for an optimal inversion‐transfer sequence. The validity of these theoretical results was checked experimentally with a solution of N , N ‐dimethylacetamide in which chemical exchange arises from internal hindered rotation. Copyright © 2015 John Wiley & Sons, Ltd.