Premium
Developments and advances concerning the hyperpolarisation technique SABRE
Author(s) -
Mewis Ryan E.
Publication year - 2015
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4280
Subject(s) - chemistry , spin isomers of hydrogen , singlet state , analyte , molecule , chemical physics , signal (programming language) , nanotechnology , atomic physics , hydrogen , physics , materials science , organic chemistry , excited state , computer science , programming language
To overcome the inherent sensitivity issue in NMR and MRI, hyperpolarisation techniques are used. Signal Amplification By Reversible Exchange (SABRE) is a hyperpolarisation technique that utilises para hydrogen, a molecule that possesses a nuclear singlet state, as the source of polarisation. A metal complex is required to break the singlet order of para hydrogen and, by doing so, facilitates polarisation transfer to analyte molecules ligated to the same complex through the J ‐coupled network that exists. The increased signal intensities that the analyte molecules possess as a result of this process have led to investigations whereby their potential as MRI contrast agents has been probed and to understand the fundamental processes underpinning the polarisation transfer mechanism. As well as discussing literature relevant to both of these areas, the chemical structure of the complex, the physical constraints of the polarisation transfer process and the successes of implementing SABRE at low and high magnetic fields are discussed. Copyright © 2015 John Wiley & Sons, Ltd.