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CLIP–ASAP‐HSQC for fast and accurate extraction of one‐bond couplings from isotropic and partially aligned molecules
Author(s) -
Becker Johanna,
Luy Burkhard
Publication year - 2015
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4276
Subject(s) - heteronuclear single quantum coherence spectroscopy , heteronuclear molecule , chemistry , molecule , isotropy , two dimensional nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , chemical physics , molecular physics , stereochemistry , optics , physics , chromatography , organic chemistry
Fast measurement of heteronuclear one‐bond couplings, a class of NMR parameters valuable for structure elucidation, is highly desirable, especially if samples undergo chemical reactions or dynamic processes are observed. Methods presented so far face severe limitations in terms of resolution, accessible bandwidth, and sensitivity. We present the CLean InPhase‐Acceleration by Sharing Adjacent Polarization‐HSQC (CLIP‐ASAP‐HSQC) pulse sequence that allows fast acquisition of spectra with clean inphase multiplets in about 25 s. The performance in terms of accurate extraction of one‐bond couplings is demonstrated on three test samples including partially aligned molecules. Copyright © 2015 John Wiley & Sons, Ltd.