Premium
Reaction monitoring using online vs tube NMR spectroscopy: seriously different results
Author(s) -
Foley David A.,
Dunn Anna L.,
Zell Mark T.
Publication year - 2016
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4259
Subject(s) - chemistry , nuclear magnetic resonance spectroscopy , fluorine 19 nmr , proton nmr , reaction rate , kinetic energy , analytical chemistry (journal) , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr , nuclear magnetic resonance , catalysis , organic chemistry , stereochemistry , physics , quantum mechanics
We report findings from the qualitative evaluation of nuclear magnetic resonance (NMR) reaction monitoring techniques of how each relates to the kinetic profile of a reaction process. The study highlights key reaction rate differences observed between the various NMR reaction monitoring methods investigated: online NMR, static NMR tubes, and periodic inversion of NMR tubes. The analysis of three reaction processes reveals that rates derived from NMR analysis are highly dependent on monitoring method. These findings indicate that users must be aware of the effect of their monitoring method upon the kinetic rate data derived from NMR analysis. Copyright © 2015 John Wiley & Sons, Ltd.