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Dynamic NMR study of cyclic derivatives of pyridoxine
Author(s) -
Rakhmatullin I.Z.,
Galiullina L.F.,
Garipov M.R.,
Strel'nik A.D.,
Shtyrlin Y.G.,
Klochkov V.V.
Publication year - 2014
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4123
Subject(s) - chemistry , two dimensional nuclear magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , nuclear overhauser effect , ring (chemistry) , pyridoxine , proton nmr , carbon 13 nmr satellite , stereochemistry , spectroscopy , acetal , fluorine 19 nmr , organic chemistry , biochemistry , physics , quantum mechanics
A series of pyridoxine derivatives was investigated by 1 H and 2D nuclear overhauser enhancement spectroscopy (NOESY) NMR. The free energies of activation for the pyridyl‐oxygen rotation of the 2,4‐dinitrophenyl ether of the seven‐membered acetals of pyridoxine were measured by dynamic NMR. A conformational exchange between the chair and twist forms of the seven‐membered acetal ring was confirmed by dynamic NMR and STO3G computations. Copyright © 2014 John Wiley & Sons, Ltd.