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Evaluation of the separation performance of polyvinylpyrrolidone as a virtual stationary phase for chromatographic NMR
Author(s) -
Huang Shaohua,
Wu Rui,
Bai Zhengwu,
Yang Ying,
Li Suying,
Dou Xiaowei
Publication year - 2014
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4102
Subject(s) - chemistry , polyvinylpyrrolidone , diffusion , solvent , resolution (logic) , xylene , phase (matter) , analytical chemistry (journal) , viscosity , chromatography , benzyl alcohol , polarity (international relations) , toluene , organic chemistry , thermodynamics , physics , biochemistry , artificial intelligence , computer science , cell , catalysis
Polyvinylpyrrolidone (PVP) was used as a virtual stationary phase to separate p ‐xylene, benzyl alcohol, and p ‐methylphenol by the chromatographic NMR technique. The effects of concentration and weight‐average molecular weight (Mw) of PVP, solvent viscosity, solvent polarity, and sample temperature on the resolution of these components were investigated. It was found that both higher PVP concentration and higher PVP Mw caused the increase of diffusion resolution for the three components. Moreover, the diffusion resolution did not change at viscosity‐higher solvents. Moreover, the three components showed different resolution at different solvents. As temperature increased, the diffusion resolution between p ‐xylene and benzyl alcohol gradually increased, and the one between p ‐xylene and p ‐methylphenol slightly increased from 278 to 298 K and then decreased above 298 K. It was also found that the polarity of the analytes played an important role for the separation by affecting the diffusion coefficient. Copyright © 2014 John Wiley & Sons, Ltd.