1 H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE‐ β ‐CD and  β ‐CD | Zendy

Martins Lucas | Zendy; Arrais Monica | Zendy; Souza Alexandre | Zendy; Marsaioli Anita | Zendy

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1 H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE‐ β ‐CD and β ‐CD

Author(s) -

Martins Lucas,

Arrais Monica,

Souza Alexandre,

Marsaioli Anita

Publication year - 2014

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.4087

Subject(s) - chemistry , dapsone , ternary operation , phosphatidylcholine , proton nmr , supramolecular chemistry , liposome , cyclodextrin , diffusion , stereochemistry , crystallography , chromatography , membrane , thermodynamics , crystal structure , biochemistry , medicine , phospholipid , dermatology , computer science , programming language , physics

Binary and ternary systems composed of dapsone, sulfobutylether‐ β ‐cyclodextrin (SBE‐ β ‐CD), β ‐CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/ β ‐CD ( K a 1396 l mol −1 ), Dap/SBE‐ β ‐CD ( K a 246 l mol −1 ), Dap/EPC ( K a 84 l mol −1 ) and the ternary complex Dap/ β ‐CD/EPC ( K a 18 l mol −1 ) in which dapsone is more soluble. Copyright © 2014 John Wiley & Sons, Ltd.

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