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1 H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE‐ β ‐CD and β ‐CD
Author(s) -
Martins Lucas,
Arrais Monica,
Souza Alexandre,
Marsaioli Anita
Publication year - 2014
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4087
Subject(s) - chemistry , dapsone , ternary operation , phosphatidylcholine , proton nmr , supramolecular chemistry , liposome , cyclodextrin , diffusion , stereochemistry , crystallography , chromatography , membrane , thermodynamics , crystal structure , biochemistry , medicine , phospholipid , dermatology , computer science , programming language , physics
Binary and ternary systems composed of dapsone, sulfobutylether‐ β ‐cyclodextrin (SBE‐ β ‐CD), β ‐CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/ β ‐CD ( K a 1396 l mol −1 ), Dap/SBE‐ β ‐CD ( K a 246 l mol −1 ), Dap/EPC ( K a 84 l mol −1 ) and the ternary complex Dap/ β ‐CD/EPC ( K a 18 l mol −1 ) in which dapsone is more soluble. Copyright © 2014 John Wiley & Sons, Ltd.