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Quantitative 2D liquid‐state NMR
Author(s) -
Giraudeau P.
Publication year - 2014
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4067
Subject(s) - chemistry , quantitative analysis (chemistry) , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , chromatography , organic chemistry
Two‐dimensional liquid‐state NMR has a very high potential to simultaneously determine the absolute concentration of small molecules in complex mixtures, thanks to its capacity to separate overlapping resonances. However, 2D NMR experiments suffer from a number of limitations which affect their quantitative performance. The last ten years have witnessed an increasing number of contributions where quantitative approaches based on 2D NMR were developed and applied to solve real analytical issues. In this review special feature article, Dr. Patrick Giraudeau (University of Nantes) describes these recent efforts to reach a high trueness and precision in quantitative measurements by 2D NMR. Different strategies are presented in a critical way, combining NMR developments with analytical chemistry protocols. The recent efforts to speed up the duration of quantitative 2D NMR experiments are particularly highlighted.