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Structure determination of two new indole‐diterpenoids from Penicillium sp. CM‐7 by NMR spectroscopy
Author(s) -
Zhang YuHong,
Huang ShengDong,
Pan HuaQi,
Bian XiQing,
Wang ZaiYing,
Han AiHong,
Bai Jiao
Publication year - 2014
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4065
Subject(s) - chemistry , circular dichroism , two dimensional nuclear magnetic resonance spectroscopy , indole test , nuclear magnetic resonance spectroscopy , stereochemistry , spectroscopy , penicillium , physics , food science , quantum mechanics
Two new indole‐diterpenoids 4b‐deoxy‐1′‐ O ‐acetylpaxilline (1) and 4b‐deoxypenijanthine A (2) were isolated from the fermentation broth and the mycelia of the soil fungus Penicillium sp. CM‐7, along with three known structurally related compounds, 1′‐ O ‐acetylpaxilline (3), paspaline (4) and 3‐deoxo‐4b‐deoxypaxilline (5). The structures of compounds 1 and 2 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Copyright © 2014 John Wiley & Sons, Ltd.