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Comparison of 1 H– 19 F two‐dimensional NMR scalar coupling correlation pulse sequences
Author(s) -
Marchione Alexander A.,
Dooley Rebecca J.,
Conklin Breanna
Publication year - 2014
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4052
Subject(s) - chemistry , pulse sequence , heteronuclear single quantum coherence spectroscopy , scalar (mathematics) , two dimensional nuclear magnetic resonance spectroscopy , coupling (piping) , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , stereochemistry , physics , chromatography , mechanical engineering , geometry , mathematics , engineering
The effectiveness of hetero‐COSY, HETCOR, HMQC, and HSQC two‐dimensional NMR pulse sequences for detection of 19 F– 1 H correlations by scalar coupling was evaluated on monofluorinated and polyfluorinated test compounds. All four of these sequences were effective in observing 1 H– 19 F correlations, using either 19 F or 1 H as the observe nucleus. All four sequences were amenable, to some degree, to adjustment to observe larger or smaller couplings preferentially. A 1/2J echo filter was effectively applied to remove artifacts from 2 J FF strong coupling. The HETCOR experiments afforded the best overall combination of sensitivity, resolution and selectivity for J HF . Copyright © 2014 John Wiley & Sons, Ltd.