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Synthesis and NMR studies of novel chromone‐2‐carboxamide derivatives
Author(s) -
Gaspar Alexandra,
Cagide Fernando,
Quezada Elias,
Reis Joana,
Uriarte Eugenio,
Borges Fernanda
Publication year - 2013
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.3937
Subject(s) - chromone , chemistry , carboxamide , ring (chemistry) , stereochemistry , drug discovery , combinatorial chemistry , organic chemistry , biochemistry
Chromones are heterocyclic compounds of natural or synthetic origin that possess relevant pharmacological activities. Versatile functionalization of the chromone nucleus allows attaining of a chemical diversity suitable to perform structure–activity relationships in drug discovery and development programs. Accordingly, the synthesis and identification of novel chromone carboxamide derivatives with electron‐donating and electron‐withdrawing substituents in different positions of the exocyclic ring are reported in this work. Their complete structural characterization was performed using one‐dimensional and two‐dimensional resonance techniques. The data acquired are useful for a prompt analysis of related compounds that encompass our integrated medicinal chemistry sketch. Copyright © 2013 John Wiley & Sons, Ltd.