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Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide‐based gels
Author(s) -
Schmidt Manuel,
Sun Han,
Leonov Andrei,
Griesinger Christian,
Reinscheid Uwe M.
Publication year - 2012
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.3886
Subject(s) - chemistry , enantiomer , residual dipolar coupling , strychnine , anisotropy , methanol , chirality (physics) , dimethyl sulfoxide , nuclear magnetic resonance spectroscopy , chromatography , organic chemistry , biochemistry , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
A new chiral alignment medium for dimethyl sulfoxide, methanol, and water as solvents was developed. Because both enantiomers of the gel are available, it is possible to enantiodiscriminate natural products such as strychnine HCl that naturally occurs as single enantiomer. With the two methods of achieving anisotropy, namely stretching and confinement, the degree of alignment can be adjusted, and the director changed from horizontal to vertical. This increases the applicability. Three compounds were enantiodiscriminated on the basis of residual dipolar coupling data: mefloquine HCl, strychnine HCl, and menthylamine HCl. Copyright © 2012 John Wiley & Sons, Ltd.