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Characterization of an unusual ring‐contraction degradant of the antifungal agent posaconazole
Author(s) -
Feng Wenqing,
Hilton Bruce D.,
Zhong Wendy,
Yang Jiong,
Yang Xi,
Tong Weidong,
Martin Gary E.
Publication year - 2012
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.3835
Subject(s) - chemistry , piperazine , posaconazole , moiety , stereochemistry , antifungal , ring (chemistry) , combinatorial chemistry , organic chemistry , microbiology and biotechnology , amphotericin b , biology
Posaconazole, a clinically useful antifungal agent, has several known oxidative degradation products involving the piperazine ring near the center of the molecule. A novel degradant was recently isolated and characterized spectroscopically as a novel ring‐contraction product incorporating a dihydroimidazolium moiety in lieu of the normally present piperazine ring. Copyright © 2012 John Wiley & Sons, Ltd.