Characterization of an unusual ring‐contraction degradant of the antifungal agent posaconazole | Zendy

Feng Wenqing | Zendy; Hilton Bruce D. | Zendy; Zhong Wendy | Zendy; Yang Jiong | Zendy; Yang Xi | Zendy; Tong Weidong | Zendy; Martin Gary E. | Zendy

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Characterization of an unusual ring‐contraction degradant of the antifungal agent posaconazole

Author(s) -

Feng Wenqing,

Hilton Bruce D.,

Zhong Wendy,

Yang Jiong,

Yang Xi,

Tong Weidong,

Martin Gary E.

Publication year - 2012

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.3835

Subject(s) - chemistry , piperazine , posaconazole , moiety , stereochemistry , antifungal , ring (chemistry) , combinatorial chemistry , organic chemistry , microbiology and biotechnology , amphotericin b , biology

Posaconazole, a clinically useful antifungal agent, has several known oxidative degradation products involving the piperazine ring near the center of the molecule. A novel degradant was recently isolated and characterized spectroscopically as a novel ring‐contraction product incorporating a dihydroimidazolium moiety in lieu of the normally present piperazine ring. Copyright © 2012 John Wiley & Sons, Ltd.

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