The structure of glibenclamide in the solid state | Zendy

Sanz Dionisia | Zendy; Claramunt Rosa M. | Zendy; Alkorta Ibon | Zendy; SánchezSanz Goar | Zendy; Elguero José | Zendy

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The structure of glibenclamide in the solid state

Author(s) -

Sanz Dionisia,

Claramunt Rosa M.,

Alkorta Ibon,

SánchezSanz Goar,

Elguero José

Publication year - 2012

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.2868

Subject(s) - glibenclamide , chemistry , tautomer , solid state , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , endocrinology , medicine , diabetes mellitus

The structure of glibenclamide, 5‐chloro‐N‐(2‐{4‐[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)‐2‐methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected. Copyright © 2012 John Wiley & Sons, Ltd.

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