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The structure of glibenclamide in the solid state
Author(s) -
Sanz Dionisia,
Claramunt Rosa M.,
Alkorta Ibon,
SánchezSanz Goar,
Elguero José
Publication year - 2012
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2868
Subject(s) - glibenclamide , chemistry , tautomer , solid state , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , endocrinology , medicine , diabetes mellitus
The structure of glibenclamide, 5‐chloro‐N‐(2‐{4‐[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)‐2‐methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected. Copyright © 2012 John Wiley & Sons, Ltd.