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Tupisteroide A–C, three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis
Author(s) -
Liu ChengXiong,
Guo Zhiyong,
Xue YanHong,
Zhang HongYan,
Zhang HongQi,
Zou Kun,
Huang NianYu
Publication year - 2012
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2861
Subject(s) - chemistry , heteronuclear molecule , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , cytotoxicity , nuclear magnetic resonance spectroscopy , cancer cell lines , spectroscopy , in vitro , cancer cell , biochemistry , cancer , medicine , physics , quantum mechanics
Three new steroidal compounds with polyhydroxy groups, tupisteroide A–C (1–3), were obtained from the roots of Tupistra chinensis , together with one known compound (4) that was isolated from this plant for the first time. The structures of tupisteroide A–C were determined on the basis of one‐ and two‐dimensional NMR spectroscopy, including 1 H– 1 H Correlation Spectroscopy, Heteronuclear Multiple Bond Correlation, and Heteronuclear Single Quantum Coherence experiments. The isolated compounds were evaluated for their cytotoxic activities against A549, HepG2, and CaSki cancer cell lines in vitro . Among them, compounds 1, 2, and 4 did not show significant inhibitory activity, but compound 3 showed cytotoxicity against A549 cancer cell lines with IC 50 values of 25.0 μM. Copyright © 2012 John Wiley & Sons, Ltd.