Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy | Zendy

Tang Chu | Zendy; Zhu Linhui | Zendy; Li Jun | Zendy; Qin Rui | Zendy; Liu Chang | Zendy; Chen Yu | Zendy; Yang Guangzhong | Zendy

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Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy

Author(s) -

Tang Chu,

Zhu Linhui,

Li Jun,

Qin Rui,

Liu Chang,

Chen Yu,

Yang Guangzhong

Publication year - 2012

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.2845

Subject(s) - chemistry , oleanolic acid , heteronuclear single quantum coherence spectroscopy , conjugate , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , chalcone , nuclear magnetic resonance spectroscopy , proton nmr , acarbose , combinatorial chemistry , organic chemistry , enzyme , medicine , mathematical analysis , alternative medicine , mathematics , pathology

Five new conjugates of oleanolic acid derivatives and chalcones have been designed and synthesized. The structure elucidation of these conjugates was accomplished by using extensive 1D ( 1 H, 13 C) and 2D NMR spectroscopic studies (COSY, HSQC and HMBC); and α ‐glucosidase inhibitory activity is reported for these conjugates. Compound 2b (IC 50 = 47.5 µ m ) displayed much stronger activity than oleanolic acid and acarbose. Copyright © 2012 John Wiley & Sons, Ltd.

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