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Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy
Author(s) -
Tang Chu,
Zhu Linhui,
Li Jun,
Qin Rui,
Liu Chang,
Chen Yu,
Yang Guangzhong
Publication year - 2012
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2845
Subject(s) - chemistry , oleanolic acid , heteronuclear single quantum coherence spectroscopy , conjugate , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , chalcone , nuclear magnetic resonance spectroscopy , proton nmr , acarbose , combinatorial chemistry , organic chemistry , enzyme , medicine , mathematical analysis , alternative medicine , mathematics , pathology
Five new conjugates of oleanolic acid derivatives and chalcones have been designed and synthesized. The structure elucidation of these conjugates was accomplished by using extensive 1D ( 1 H, 13 C) and 2D NMR spectroscopic studies (COSY, HSQC and HMBC); and α ‐glucosidase inhibitory activity is reported for these conjugates. Compound 2b (IC 50 = 47.5 µ m ) displayed much stronger activity than oleanolic acid and acarbose. Copyright © 2012 John Wiley & Sons, Ltd.