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Regioselective synthesis and structural elucidation of 1,4‐disubstituted 1,2,3‐triazole derivatives using 1D and 2D NMR spectral techniques
Author(s) -
Babu Thelagathoti Hari,
Phani Kumar B. V. N.,
Rajeswari C.,
Perumal Paramasivan T.
Publication year - 2011
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2820
Subject(s) - chemistry , regioselectivity , benzaldehyde , cycloaddition , azide , triazole , stereochemistry , proton nmr , 1,2,3 triazole , carbon 13 nmr , combinatorial chemistry , computational chemistry , organic chemistry , catalysis
Regioselective synthesis of 2‐[1‐(2‐oxo‐2‐phenylethyl)‐1 H ‐[1,2,3]triazol‐4‐ylmethoxy]‐benzaldehyde derivatives was achieved by [3 + 2] cycloaddition reaction of 2‐(prop)‐2‐ynyloxy‐benzaldehyde derivatives with phenacyl azide. The regiochemistry and the spectral assignments of the synthesized triazole derivatives were studied using both 1D and 2D NMR spectral techniques in solution. Copyright © 2011 John Wiley & Sons, Ltd.