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DOSY‐NMR analysis of ring‐closing metathesis (RCM) products from β‐lactam precursors
Author(s) -
Sliwa Aline,
MarchandBrynaert Jacqueline,
Luhmer Michel
Publication year - 2011
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2808
Subject(s) - chemistry , metathesis , ring closing metathesis , lactam , mass spectrometry , ring (chemistry) , olefin metathesis , combinatorial chemistry , computational chemistry , organic chemistry , chromatography , polymer , polymerization
The discrimination between cyclomonomers and various oligomers formed during a ring‐closing metathesis (RCM) process is not an easy task. Their 1 H NMR patterns are often very similar, and the use of mass spectrometry techniques is usually recommended. Here, we show that the DOSY‐NMR method is a reliable tool to help in the identification of cyclomonomers versus cyclodimers by comparing the translational diffusion coefficient of the compounds issued from RCM reactions with the diffusion coefficient of their respective precursors. Copyright © 2011 John Wiley & Sons, Ltd.