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Alkaloids from Hippeastrum morelianum Lem. (Amaryllidaceae)
Author(s) -
Giordani Raquel B.,
de Andrade Jean P.,
Verli Hugo,
Dutilh Julie H.,
Henriques Amélia T.,
Berkov Strahil,
Bastida Jaume,
Zuanazzi José Angelo S.
Publication year - 2011
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2794
Subject(s) - amaryllidaceae , chemistry , two dimensional nuclear magnetic resonance spectroscopy , heteronuclear single quantum coherence spectroscopy , stereochemistry , amaryllidaceae alkaloids , methyllycaconitine , phytochemical , alkaloid , botany , biochemistry , biology , receptor , nicotinic agonist , nicotinic acetylcholine receptor
The Amaryllidaceae family has proven to be a rich source of active molecules. As part of an ongoing project, we report a phytochemical study of Hippeastrum morelianum (Amaryllidaceae), from which we have isolated two homolycorine‐type alkaloids, the new 2α,7‐dimethoxyhomolycorine (1) and the poorly described candimine (2), as well as six known alkaloids: tazettine, pretazettine, 3‐epimacronine, haemanthamine, hamayne and trisphaeridine. For reference purposes, the NMR of the isolated compounds was unequivocally described, based on 2D NMR measurements including 1 H– 1 H COSY, 1 H– 1 H NOESY, HSQC and HMBC. Copyright © 2011 John Wiley & Sons, Ltd.