Premium
1 H and 13 C assignments of two new macrocyclic lactones isolated from Streptomyces sp. 211726 and revised assignments of Azalomycins F 3a , F 4a and F 5a
Author(s) -
Yuan Ganjun,
Lin Haipeng,
Wang Cheng,
Hong Kui,
Liu Yue,
Li Jia
Publication year - 2011
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2697
Subject(s) - chemistry , stereochemistry , dept , streptomyces , nmr spectra database , two dimensional nuclear magnetic resonance spectroscopy , proton , proton nmr , heteronuclear single quantum coherence spectroscopy , spectral line , bacteria , genetics , physics , quantum mechanics , astronomy , biology
Azalomycin F 4a 2‐ethylpentyl ester (1) and Azalomycin F 5a 2‐ethylpentyl ester (2), two new macrocyclic lactones, along with three known compounds of Azalomycins F 3a (3), F 4a (4) and F 5a (5), were identified from metabolites of Streptomyces sp. 211726 isolated from mangrove rhizosphere soil. The complete 1 H and 13 C assignments of these compounds were achieved by using 1 H, 13 C, DEPT, HSQC, 1 H‐ 1 H COSY and HMBC spectra, and the relative stereochemistry of 5 was first elucidated on the basis of proton–proton coupling constants, NOESY and IR spectra. Moreover, some errors in the 1 H and 13 C assignments published of 3, 4 and 5 were found and revised. 1 and 2 were active against Candida albicans , and exhibited moderate cyctotoxicity against HCT‐116 cell line. Copyright © 2010 John Wiley & Sons, Ltd.