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Complete assignment of the 1 H and 13 C NMR spectra of antimicrobial 4‐arylamino‐ 3‐nitrocoumarin derivatives
Author(s) -
Dekić Vidoslav,
Radulović Niko,
Vukićević Rastko,
Dekić Biljana,
Skropeta Danielle,
Palić Radosav
Publication year - 2010
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2681
Subject(s) - chemistry , chemical shift , heteronuclear single quantum coherence spectroscopy , moiety , carbon 13 nmr , nmr spectra database , carbon 13 nmr satellite , two dimensional nuclear magnetic resonance spectroscopy , antimicrobial , proton nmr , stereochemistry , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , spectral line , organic chemistry , physics , astronomy
Herein, we describe the synthesis and complete assignment of the 1 H and 13 C NMR chemical shifts of a series of antimicrobial 4‐arylamino‐3‐nitrocoumarin derivatives based on a combination of 1 H and 13 C NMR, 1 H‐ 1 H‐COSY, NOESY, HSQC and HMBC experiments. Conformational effects upon the chemical shifts of the coumarin moiety arising from the anisotropy of the aryl side group are briefly discussed. This study provides the first complete and fully assigned NMR data for this important group of antimicrobial compounds and bridges the gap existing in the literature with regard to NMR structural data for 4‐arylamino‐3‐nitrocoumarins. Copyright © 2010 John Wiley & Sons, Ltd.