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Fast multidimensional localized parallel NMR spectroscopy for the analysis of samples
Author(s) -
VegaVazquez Marino,
Cobas Juan Carlos,
MartinPastor Manuel
Publication year - 2010
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2659
Subject(s) - chemistry , nuclear magnetic resonance spectroscopy , spectroscopy , fluorine 19 nmr , two dimensional nuclear magnetic resonance spectroscopy , transverse relaxation optimized spectroscopy , computational chemistry , nuclear magnetic resonance , analytical chemistry (journal) , stereochemistry , organic chemistry , quantum mechanics , physics
A parallel localized spectroscopy (PALSY) method is presented to speed up the acquisition of multidimensional NMR (nD) spectra. The sample is virtually divided into a discrete number of nonoverlapping slices that relax independently during consecutive scans of the experiment, affording a substantial reduction in the interscan relaxation delay and the total experiment time. PALSY was tested for the acquisition of three experiments 2D COSY, 2D DQF‐COSY and 2D TQF‐COSY in parallel, affording a time‐saving factor of 3–4. Some unique advantages are that the achievable resolution in any dimension is not compromised in any way: it uses conventional NMR data processing, it is not prone to generate spectral artifacts, and once calibrated, it can be used routinely with these and other combinations of NMR spectra. Copyright © 2010 John Wiley & Sons, Ltd.