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Structure determination of selaginellins G and H from Selaginella pulvinata by NMR spectroscopy
Author(s) -
Cao Yuan,
Chen JiJun,
Tan NingHua,
Wu YongPing,
Yang Jie,
Wang Qiang
Publication year - 2010
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2623
Subject(s) - chemistry , selaginella , heteronuclear single quantum coherence spectroscopy , candida albicans , nuclear magnetic resonance spectroscopy , stereochemistry , antifungal , two dimensional nuclear magnetic resonance spectroscopy , botany , microbiology and biotechnology , biology
Selaginellins G ( 1 ) and H ( 2 ), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata . Their structures were elucidated, and complete assignments of the 1 H and 13 C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC 50 value of 5.3 µg/ml. Copyright © 2010 John Wiley & Sons, Ltd.