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NMR studies on chiral intermediates in the total synthesis of (+)‐biotin from D ‐mannose
Author(s) -
Chen Wenxue,
Zhang Ping,
Chen Fener
Publication year - 2010
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2619
Subject(s) - chemistry , heteronuclear single quantum coherence spectroscopy , total synthesis , mannose , biotin , dept , stereochemistry , proton nmr , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , biochemistry
The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)‐biotin starting from D ‐mannose as chiral pool were completely assigned using one‐ and two‐dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC. Copyright © 2010 John Wiley & Sons, Ltd.
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