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Structure elucidation of new oleanane‐type glycosides from three species of Acanthophyllum
Author(s) -
Timité Gaoussou,
MitaineOffer AnneClaire,
Miyamoto Tomofumi,
Ramezani Mohammad,
Rustaiyan Abdolhossein,
Mirjolet JeanFrançois,
Duchamp Olivier,
LacailleDubois MarieAleth
Publication year - 2010
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2577
Subject(s) - chemistry , oleanane , glycoside , caryophyllaceae , stereochemistry , cytotoxicity , two dimensional nuclear magnetic resonance spectroscopy , triterpene , botany , biochemistry , in vitro , medicine , alternative medicine , pathology , biology
From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum , together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23‐ O ‐β‐ D ‐galactopyranosylgypsogenic acid‐28‐ O ‐β‐ D ‐glucopyranosyl‐(1→3)‐[β‐ D ‐glucopyranosyl‐(1→6)]‐β‐ D ‐galactopyranoside (1) and gypsogenic acid‐28‐ O ‐β‐ D ‐glucopyranosyl‐(1→3)‐[β‐ D ‐glucopyranosyl‐(1→6)]‐β‐ D ‐galactopyranoside (2). The cytotoxicity of several of these saponins was evaluated against two human colon cancer cell lines (HT‐29 and HCT 116). Copyright © 2010 John Wiley & Sons, Ltd.
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