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Structural determination of aspericins AC, new furan and pyran derivates from the marine‐derived fungus Rhizopus sp. 2‐PDA‐61, by 1D and 2D NMR spectroscopy
Author(s) -
Wang Fazuo,
Zhu Tianjiao,
Zhang Min,
Lin Aiqun,
Zhu Weiming,
Gu Qianqun
Publication year - 2010
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2545
Subject(s) - chemistry , dept , two dimensional nuclear magnetic resonance spectroscopy , furan , pyran , stereochemistry , carbon 13 nmr , nuclear magnetic resonance spectroscopy , rhizopus , fungus , marine fungi , organic chemistry , botany , fermentation , biology
Three new furan and pyran derivatives named aspericins AC (1–3), as well as a known asperic acid (4), have been isolated from the marine‐derived fungus Rhizopus sp. 2‐PDA‐61. The complete 1 H and 13 C NMR assignments for the new compounds were carried out using 1 H, 13 C, DEPT, COSY, HMQC, HMBC, and NOESY NMR experiments. Compounds 1–3 were evaluated for their cytotoxic activities on P388, A549, HL‐60, and BEL‐7420 cell lines by the MTT and SRB methods. Copyright © 2009 John Wiley & Sons, Ltd.