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Structure elucidation and 1 H/ 13 C NMR spectral assignments of four trabectedin related compounds
Author(s) -
Vermeulen Wim,
Filliers Walter,
García Carmen,
Manzanaro Sonia,
Montalvo David,
Polanco Concepción,
Spillemaeckers Frank,
Van Hoof Bart,
Winderickx Guido,
Somers Ivan,
RodriguezCampos Ignacio
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2334
Subject(s) - chemistry , carbon 13 nmr , stereochemistry , nuclear magnetic resonance spectroscopy , combinatorial chemistry
Abstract This article presents the structure elucidation of four new compounds, formed during the hemisynthetic preparation of trabectedin, an anti‐tumor natural product from Ecteinascidia turbinata . We report herein on the use of UV, MS and NMR spectroscopic data along with 1 H and 13 C spectral assignments obtained by means of 1D and 2D homo‐ and heteronuclear NMR techniques. Copyright © 2008 John Wiley & Sons, Ltd.