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NMR spectroscopic elucidation of the structure and stereochemistry of tricyclic 3‐styrylpyrazolines
Author(s) -
Tóth Gábor,
Simon András,
Jenei Attila,
Jekő József,
Lévai Albert
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2309
Subject(s) - diastereomer , chemistry , tricyclic , stereochemistry , thio , column chromatography , acetic acid , organic chemistry
Diastereomeric mixtures of tricyclic 3‐styrylpyrazolines have been prepared by the reaction of 3‐cynnamylidenechroman‐4‐ones and their 1‐thio analogs with hydrazine in hot acetic acid or propionic acid solutions. The diastereomeric mixtures were separated by column chromatography to obtain the pure diastereomers. The elucidation of their structure and stereochemistry and complete 1 H and 13 C assignments have been performed by a combination of various one‐ and two‐dimensional NMR experiments. Copyright © 2008 John Wiley & Sons, Ltd.