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Complete 1 H and 13 C NMR spectral assignment of benzo[ d ]isothiazole derivatives and of an isoindole isoster
Author(s) -
Incerti Matteo,
Acquotti Domenico,
Vicini Paola
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2308
Subject(s) - chemistry , isothiazole , stereochemistry , heteronuclear single quantum coherence spectroscopy , carbon 13 nmr , two dimensional nuclear magnetic resonance spectroscopy , medicinal chemistry
The complete 1 H and 13 C NMR assignments of the novel compound methyl 2‐amino‐3‐(benzo[ d ]isothiazol‐3‐yl)propanoate (1), of 3‐amino‐5‐methylbenzo[ d ]isothiazole (2) and N ‐( t ‐butyloxycarbonyl)‐2‐aminobenzo[ d ]isothiazol‐3(2 H )‐one (3) and of the desulfurated isostere of 3, N ‐( t ‐butyloxycarbonyl)‐2‐aminoisoindolin‐1‐one (4), using 1D and 2D NMR techniques, including COSY, INADEQUATE, HSQC, and HMBC experiments are reported. Copyright © 2008 John Wiley & Sons, Ltd.