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Structure elucidation of two new xanthone derivatives from the marine fungus Penicillium sp. (ZZF 32#) from the South China Sea
Author(s) -
Shao Changlun,
Wang Changyun,
Wei Meiyan,
Gu Yucheng,
Xia Xuekui,
She Zhigang,
Lin Yongcheng
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2293
Subject(s) - xanthene , chemistry , xanthone , mangrove , stereochemistry , fungus , penicillium , marine fungi , cytotoxicity , carbon 13 nmr , organic chemistry , biochemistry , botany , food science , biology , in vitro , ecology
Two new xanthones, 8‐(methoxycarbonyl)‐1‐hydroxy‐9‐oxo‐9H‐xanthene‐3‐carboxylic acid (1) and dimethyl 8‐methoxy‐9‐oxo‐9H‐xanthene‐1, 6‐dicarboxylate (2) and one known xanthone methyl 8‐hydroxy‐6‐methyl‐9‐oxo‐9H‐xanthene‐1‐carboxylate (3) were isolated from the culture broth of the mangrove fungus Penicillium sp. (ZZF 32#) collected from the South China Sea. Their structures were established by comprehensive analysis of one‐dimensional (1D) and two‐dimensional (2D) NMR data. The structure of compound 3 was confirmed by X‐ray crystallography, which led to the suggestion that janthinone (4) might have the same structure as 3. Compounds 1–3 were inactive against KB or KBv200 cells during cytotoxicity evaluations. Copyright © 2008 John Wiley & Sons, Ltd.