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Selective HOESY experiments for stereochemical determinations
Author(s) -
Yemloul Mehdi,
BouguetBonnet Sabine,
Ba Lalla Aïcha,
Kirsch Gilbert,
Canet Daniel
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2283
Subject(s) - chemistry , heteronuclear molecule , nuclear overhauser effect , sensitivity (control systems) , relaxation (psychology) , nuclear magnetic resonance spectroscopy , molecule , nuclear magnetic resonance , spectroscopy , proton , dipole , analytical chemistry (journal) , stereochemistry , chromatography , organic chemistry , psychology , social psychology , physics , quantum mechanics , electronic engineering , engineering
Heteronuclear Overhauser effect spectroscopy (HOESY) is a powerful method for tracking geometrical proximities between two heteronuclei (for instance, 1 H and 13 C, as this will be the case here). The method is based on cross‐relaxation arising from dipolar interactions. Sensitivity permitting, it is applied in the 2D mode yielding all spatial correlations in a single experiment. Whenever sensitivity is not sufficient, it can be applied in the one‐dimensional mode by selectively inverting one particular proton. In that case, it yields, from the carbon‐13 spectrum, remote spatial correlations. The method has been employed here for the discrimination between two possible E or Z isomers in a medium‐size molecule. Copyright © 2008 John Wiley & Sons, Ltd.