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NMR studies of novel Schiff bases derived from L ‐α‐amino methyl esters and 3‐hydroxypyridin‐4‐carboxaldehyde
Author(s) -
Perona Almudena,
Sanz Dionisia,
Claramunt Rosa M.,
Elguero José
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2278
Subject(s) - chemistry , pyridine , proton nmr , stereochemistry , schiff base , density functional theory , nuclear magnetic resonance spectroscopy , medicinal chemistry , computational chemistry
Schiff bases of 3‐hydroxypyridin‐4‐carboxaldehyde and L ‐α‐amino esters as well as those derived from the structurally related amines lacking the ester function have been synthesised. In two cases a tetrahydro‐1 H ‐imidazo[4,5‐ c ]pyridine was formed as a by‐product. 1 H, 13 C, 15 N‐NMR spectral data and density functional theory (DFT) calculations established the structure of all compounds. Copyright © 2008 John Wiley & Sons, Ltd.