Premium
Complete and unambiguous assignments of 1 H and 13 C chemical shifts of new arylamino derivatives of ortho ‐naphthofuranquinones
Author(s) -
da Silva Júnior Eufrânio N.,
de Souza Maria Cecília B. V.,
Pinto Antônio V.,
Pinto Maria do Carmo F. R.,
Nogueira Christiane M.,
Ferreira Vitor F.,
Azeredo Rodrigo B. V.
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2250
Subject(s) - chemistry , chemical shift , heteronuclear single quantum coherence spectroscopy , stereochemistry , carbon 13 nmr , two dimensional nuclear magnetic resonance spectroscopy
Abstract Six new nor‐β‐lapachones have been synthesized from reaction of 3‐bromo‐nor‐β‐lapachone with arylamines. These derivatives have potent anticancer properties against several cell lines. Here, we report complete unambiguous assignments of 1 H and 13 C chemical shifts of the new compounds. The assignments were made using a combination of one‐ and two‐dimensional NMR techniques ( 1 H, 13 C, 1 H 1 H COSY, 1 H 13 C HSQC, and 1 H 13 C HMBC). Copyright © 2008 John Wiley & Sons, Ltd.