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Microbial transformation of the diterpene mulin‐11,13‐dien‐20‐oic acid by Mucor plumbeus
Author(s) -
Areche Carlos,
Loyola Luis A.,
Borquez Jorge,
Rovirosa Juana,
SanMartin Aurelio
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2238
Subject(s) - chemistry , diterpene , stereochemistry , transformation (genetics) , biochemistry , gene
Two new mulinane‐type derivatives: 16‐hydroxy mulin‐11,13‐dien‐20‐oic (2) acid and 7α,16‐dihydroxy mulin‐11,13‐dien‐20‐oic (3) acid were obtained by microbial transformation of mulin‐11,13‐dien‐20‐oic acid (1), along with tyrosol (4) using liquid cultures of Mucor plumbeus . The latter compound has not been previously identified in the genus Mucor . Structural elucidation of these metabolites was achieved using 1D‐ and 2D‐NMR spectroscopy. Copyright © 2008 John Wiley & Sons, Ltd.