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Using indirect covariance spectra to identify artifact responses in unsymmetrical indirect covariance calculated spectra
Author(s) -
Martin Gary E.,
Hilton Bruce D.,
Blinov Kirill A.,
Williams Antony J.
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2141
Subject(s) - heteronuclear single quantum coherence spectroscopy , covariance , chemistry , heteronuclear molecule , two dimensional nuclear magnetic resonance spectroscopy , artifact (error) , spectral line , nmr spectra database , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , statistics , stereochemistry , mathematics , chromatography , artificial intelligence , physics , computer science , quantum mechanics
Abstract Several groups of authors have reported studies in the areas of indirect and unsymmetrical indirect covariance NMR processing methods. Efforts have recently focused on the use of unsymmetrical indirect covariance processing methods to combine various discrete two‐dimensional NMR spectra to afford the equivalent of the much less sensitive hyphenated 2D NMR experiments, for example indirect covariance (icv)‐heteronuclear single quantum coherence (HSQC)‐COSY and icv‐HSQC–nuclear Overhauser effect spectroscopy (NOESY). Alternatively, unsymmetrical indirect covariance processing methods can be used to combine multiple heteronuclear 2D spectra to afford icv‐ 13 C 15 N HSQC‐HMBC correlation spectra. We now report the use of responses contained in indirect covariance processed HSQC spectra as a means for the identification of artifacts in both indirect covariance and unsymmetrical indirect covariance processed 2D NMR spectra. Copyright © 2007 John Wiley & Sons, Ltd.