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Tryptamine derived amides with thiazole ring system from Thermoactinomyces strain TA66‐2
Author(s) -
Korkmaz Çaǧla Akmemiş,
HameşKocabaş E. Esin,
Uzel Ataç,
Bedir Erdal
Publication year - 2008
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2101
Subject(s) - chemistry , tryptamine , thiazole , stereochemistry , ring (chemistry) , strain (injury) , organic chemistry , biochemistry , anatomy , medicine
Abstract A moderately thermophilic actinomycete strain, which was identified as Thermoactinomyces strain TA66‐2, was isolated from hot‐spring water. Fermentation, followed by solvent partition and chromatographic separations, resulted in the isolation of two new and two known molecules. The structures of the new compounds were elucidated as 2‐(1‐Propionylaminoethyl)thiazole‐4‐carboxylic acid [2‐(1H‐indol‐3‐yl)ethyl]amide and 2‐(1‐Acetylaminoethyl)thiazole‐4‐carboxylic acid [2‐(1H‐indol‐3‐yl)‐ethyl]amide by using spectral methods (1D‐, 2D‐NMR and LC–ESI–MS). Copyright © 2007 John Wiley & Sons, Ltd.