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QQ‐HSQC: a quick, quantitative heteronuclear correlation experiment for NMR spectroscopy
Author(s) -
Peterson Daniel J.,
Loening Nikolaus M.
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2073
Subject(s) - heteronuclear single quantum coherence spectroscopy , heteronuclear molecule , chemistry , two dimensional nuclear magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , transverse relaxation optimized spectroscopy , nuclear magnetic resonance , spectroscopy , fluorine 19 nmr , analytical chemistry (journal) , chromatography , stereochemistry , physics , quantum mechanics
Quantitative heteronuclear single quantum coherence (Q‐HSQC) is a variant of the HSQC experiment that provides quantitative peak areas. This is accomplished by combining signals acquired using four different INEPT delays. Consequently, the experiment requires four times as many scans as the HSQC experiment to achieve the same resolution in the indirect dimension. We have removed this drawback by modifying the Q‐HSQC experiment so that signals corresponding to different INEPT delays are acquired simultaneously from different parts of the sample. This new experiment, which we call Quick, Quantitative HSQC (QQ‐HSQC), has the quantitative properties of the Q‐HSQC experiment but only requires as many scans as a conventional HSQC experiment. Copyright © 2007 John Wiley & Sons, Ltd.