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SPEED: single‐point evaluation of the evolution dimension
Author(s) -
Kupče Eriks,
Freeman Ray
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2052
Subject(s) - dimension (graph theory) , sampling (signal processing) , spectral line , chemistry , amplitude , point (geometry) , spectrum (functional analysis) , statistical physics , computational physics , algorithm , physics , quantum mechanics , mathematics , optics , combinatorics , geometry , detector
Two‐dimensional NMR spectroscopy can be speeded up by orders of magnitude by severely restricting the number of sampling operations in the evolution dimension–we demonstrate that just a single measurement may suffice. The frequencies evolving in the indirect dimension ( t 1 ) are deduced from the amplitudes of the signals acquired in the direct dimension ( t 2 ). Prior measurements of the one‐dimensional spectra are required. Results are presented for the two‐dimensional 13 C‐HSQC spectrum of 2‐ethylindanone recorded at a single fixed setting of the evolution time, demonstrating a speed advantage of 120. The method can be extended to multidimensional spectra, with correspondingly greater gains in speed. Copyright © 2007 John Wiley & Sons, Ltd.