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1 H and 13 C NMR signal assignments of Paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp. (tree 1–7)
Author(s) -
Guo Zhiyong,
She Zhigang,
Shao Changlun,
Wen Lu,
Liu Fan,
Zheng Zhonghui,
Lin Yongcheng
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2035
Subject(s) - chemistry , cytotoxicity , chromone , stereochemistry , mangrove , carbon 13 nmr , two dimensional nuclear magnetic resonance spectroscopy , fungus , botany , biochemistry , in vitro , ecology , biology
Two new natural products, named paecilin A (1) and B (2), together with two known compounds secalonic acid D (3) and (11)‐cytochalasa‐6(12),13‐diene‐1,21‐dione‐16,18‐dimethyl‐7‐hydroxy‐l0‐phenyl‐(7 S *,13 E ,16 S *,18 S *) (4), were isolated from the mangrove endophytic fungus, Paecilomyces sp. (tree 1–7) from the South China Sea. 1D and 2D NMR experiments including COSY, HMQC, and HMBC were used for the determination of their structures. In our cytotoxicity assays, secalonic D (3) showed cytotoxicity toward KB cells with IC 50 < 1 µg ml −1 and inhibiting human topoisomerase I with IC 50 at 0.16 µmol ml −1 . 1, 2, and 4 showed no activity to KB cells. Copyright © 2007 John Wiley & Sons, Ltd.