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Utilizing unsymmetrical indirect covariance processing to define 15 N 13 C connectivity networks
Author(s) -
Martin Gary E.,
Irish Patrick A.,
Hilton Bruce D.,
Blinov Kirill A.,
Williams Antony J.
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2029
Subject(s) - chemistry , covariance , statistics , mathematics
There has been considerable interest over the past decade in the utilization of direct and long‐range 1 H 15 N heteronuclear shift correlation methods at natural abundance to facilitate the elucidation of small molecule structures. Recently, there has also been a high level of interest in the exploration of indirect covariance NMR methods. Our initial explorations in this area led to the development of unsymmetrical indirect covariance methods, which allow the calculation of hyphenated 2D NMR spectra such as 2D GHSQC‐COSY and GHSQC‐NOESY from the discrete component 2D NMR experiments. We now wish to report the utilization of unsymmetrical indirect covariance NMR methods for the combination of 1 H 13 C GHSQC and 1 H 15 N long‐range (GHMBC, IMPEACH‐MBC, CIGAR‐HMBC, etc.) heteronuclear chemical shift correlation spectra to determine 15 N 13 C correlation pathways. Copyright © 2007 John Wiley & Sons, Ltd.