Conformational exchange in pimonidazole—a hypoxia marker | Zendy

Gabellieri Cristina | Zendy; Eykyn Thomas R. | Zendy; Leach Martin O. | Zendy

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Conformational exchange in pimonidazole—a hypoxia marker

Author(s) -

Gabellieri Cristina,

Eykyn Thomas R.,

Leach Martin O.

Publication year - 2007

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.2024

Subject(s) - chemistry , nitroimidazole , nuclear magnetic resonance spectroscopy , molecule , two dimensional nuclear magnetic resonance spectroscopy , spectroscopy , aqueous solution , ring (chemistry) , stereochemistry , computational chemistry , organic chemistry , physics , quantum mechanics

Pimonidazole is one of a series of nitroimidazole compounds that is widely used as a marker for qualitative and quantitative assessment of tumour hypoxia. We have observed a novel dynamic conformational exchange process in this molecule in aqueous solution. By a combination of 1 H, 13 C, two‐dimensional 1 H– 1 H EXchange SpectroscopY (EXSY) and spectral simulation, we unambiguously attribute the conformational exchange process to flipping of the six‐membered heterocyclic ring. Copyright © 2007 John Wiley & Sons, Ltd.

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