Premium
Structure elucidation of thermal degradation products of amlodipine
Author(s) -
Lakshmi Devi A. Siva,
Srinivasa Rao Y.,
Satish M.,
Jyothi G.,
Babu Rao K.,
Omdutt T.
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.2022
Subject(s) - chemistry , intramolecular force , degradation (telecommunications) , amlodipine , nuclear magnetic resonance spectroscopy , stereochemistry , medicinal chemistry , organic chemistry , medicine , telecommunications , computer science , blood pressure , radiology
Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG‐I, AMLDEG‐II, and AMLDEG‐III, respectively. AMLDEG‐I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG‐II is a positional isomer of AMLDEG‐I. AMLDEG‐III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT‐IR and 1 H and 13 C NMR spectroscopy data. The AMLDEG‐III was crystallized and its structure was solved by single crystal X‐ray diffraction (SXRD). Copyright © 2007 John Wiley & Sons, Ltd.