Structure elucidation of thermal degradation products of amlodipine | Zendy

Lakshmi Devi A. Siva | Zendy; Srinivasa Rao Y. | Zendy; Satish M. | Zendy; Jyothi G. | Zendy; Babu Rao K. | Zendy; Omdutt T. | Zendy

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Structure elucidation of thermal degradation products of amlodipine

Author(s) -

Lakshmi Devi A. Siva,

Srinivasa Rao Y.,

Satish M.,

Jyothi G.,

Babu Rao K.,

Omdutt T.

Publication year - 2007

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.2022

Subject(s) - chemistry , intramolecular force , degradation (telecommunications) , amlodipine , nuclear magnetic resonance spectroscopy , stereochemistry , medicinal chemistry , organic chemistry , medicine , telecommunications , computer science , blood pressure , radiology

Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG‐I, AMLDEG‐II, and AMLDEG‐III, respectively. AMLDEG‐I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG‐II is a positional isomer of AMLDEG‐I. AMLDEG‐III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT‐IR and 1 H and 13 C NMR spectroscopy data. The AMLDEG‐III was crystallized and its structure was solved by single crystal X‐ray diffraction (SXRD). Copyright © 2007 John Wiley & Sons, Ltd.

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