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Two‐dimensional spectroscopy with parallel acquisition of 1 HX and 19 FX correlations
Author(s) -
Kupče Eriks,
Cheatham Steve,
Freeman Ray
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1988
Subject(s) - chemistry , spectroscopy , spectral line , nuclear magnetic resonance spectroscopy , heteronuclear single quantum coherence spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , nmr spectra database , analytical chemistry (journal) , crystallography , stereochemistry , physics , organic chemistry , quantum mechanics , astronomy
Two‐dimensional NMR spectra correlating both 1 H and 19 F nuclei with either 13 C or 15 N, are recorded at the same time, using a 600‐MHz broadband radio frequency probe feeding independent 1 H and 19 F receiver channels. This technique, known as parallel acquisition NMR spectroscopy (PANSY), speeds up multidimensional NMR and is compatible with other fast‐acquisition schemes. The method is illustrated with single‐bond (HSQC) and multiple‐bond (HMBC) experiments on 2‐bromophenyl‐3‐trifluoromethyl‐5‐methylpyrazole, giving simultaneous 1 HX and 19 FX correlation spectra (X = 13 C or 15 N). Copyright © 2007 John Wiley & Sons, Ltd.