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Fast multidimensional NMR by polarization sharing
Author(s) -
Kupče Eriks,
Freeman Ray
Publication year - 2007
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1931
Subject(s) - chemistry , polarization (electrochemistry) , nuclear magnetic resonance spectroscopy , stereochemistry
The speed of multidimensional NMR spectroscopy can be significantly increased by drastically shortening the customary relaxation delay between scans. The consequent loss of longitudinal magnetization can be retrieved if ‘new’ polarization is transferred from nearby spins. For correlation spectroscopy involving heteronuclei (X = 13 C or 15 N), protons not directly bound to X can repeatedly transfer polarization to the directly bound protons through Hartmann–Hahn mixing. An order of magnitude increase in speed has been observed for the 600 MHz two‐dimensional HMQC spectra of amikacin and strychnine using this technique, and it also reduces the noisy F 1 ridges that degrade many heteronuclear correlation spectra recorded with short recovery times. Copyright © 2007 John Wiley & Sons, Ltd.