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Accordion BIRD‐HMBC experiments: improved one‐bond correlation suppression in accordion heteronuclear multiple‐bond correlation‐type experiments
Author(s) -
Furrer Julien
Publication year - 2006
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1857
Subject(s) - heteronuclear molecule , accordion , chemistry , heteronuclear single quantum coherence spectroscopy , range (aeronautics) , analytical chemistry (journal) , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , chromatography , nuclear magnetic resonance spectroscopy , materials science , composite material , world wide web , computer science
Modifications of the BIRD‐HMBC experiment, in which the accordion principle and a constant time period have been introduced, are presented. With the simple accordion BIRD‐HMBC, the use of a BIRD r, X element in the middle of the variable long‐range couplings evolution period efficiently eliminates unwanted 1 J CH signals and samples a broad range of long‐range heteronuclear couplings. While the accordion BIRD‐HMBC experiment shows reduced F 1 modulation, superior suppression of unwanted 1 J CH signals and sensitivity comparable to the ACCORD‐HMBC, the addition of another constant time period suppresses F 1 modulation due to 1 H‐ 1 H coupling, while preserving the excellent suppression of unwanted 1 J CH signals. The constant‐time (CT) accordion BIRD‐HMBC experiment combines sensitivity similar to the CIGAR‐HMBC and superior suppression of unwanted 1 J CH signals. Results of identically optimized ACCORD‐HMBC, accordion BIRD‐HMBC, CT accordion BIRD‐HMBC and CIGAR‐HMBC experiments performed on a sample of strychnine are compared and discussed. Copyright © 2006 John Wiley & Sons, Ltd.