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Adiabatic JHSQC for 13 C isotopomer analysis
Author(s) -
Merritt Matthew E.,
Burgess Shawn C.,
Spitzer Timothy D.
Publication year - 2006
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1765
Subject(s) - heteronuclear molecule , isotopomers , adiabatic process , calibration , chemistry , sensitivity (control systems) , inverse , computational physics , physics , nuclear magnetic resonance spectroscopy , thermodynamics , quantum mechanics , electronic engineering , geometry , mathematics , organic chemistry , molecule , engineering
A previous implementation of JHSQC enhanced the detection limits for 13 C isotopomer analysis, but owing to experimental instabilities required extensive calibration prior to data collection.1,2 The addition of adiabatic pulses as well as a double spin‐echo during the heteronuclear transfer periods has dramatically increased the precision of the experiment and done away with the need for calibration prior to running each sample. This new experiment allows the sensitivity gains from inverse detection to be realized in a time‐efficient manner for the experimentalist. Copyright © 2006 John Wiley & Sons, Ltd.